Article Title：Genes 'for' phenotypes: A modern history view
Abstract：
We attempt to improve the understanding of the notion of a gene being 'for' a phenotypic trait or traits. Considering the implicit functional ascription of one thing being 'for' another, we submit a more restrictive version of 'gene for' talk. Accordingly, genes are only to be thought of as being for phenotypic traits when good evidence is available that the presence or prevalence of the gene in a population is the result of natural selection on that particular trait, and that the association between that trait and the gene in question is demonstrably causal. It is therefore necessary to gather statistical, biochemical, historical, as well as ecological information before properly claiming that a gene is for a phenotypic trait. Instead of hampering practical use of the 'gene for' talk, our approach aims at stimulating much needed research into the functional ecology and comparative evolutionary biology of gene action.
Keywords: direct functions; evolutionary biology; genes for; genetic trait; molecular genetics; proper function; selection
DOI: 10.1023/A:1006773112047
Source：BIOLOGY & PHILOSOPHY
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