Article Title：Sex differences in rapid auditory processing deficits in ectopic BXSB/MpJ mice
Abstract：
Prior research with rodent models, performed predominantly in males, has demonstrated a significant association between focal neocortical malformations (e.g. ectopias and microgyria) and rate-specific auditory processing deficits. In the current study and consistent with prior findings, we report that ectopic male BXSB/ MpJ mice exhibit impairments in detecting a two-tone oddball stimulus at short but not long inter-stimulus interval durations when compared to non-ectopic male littermates. However, ectopic female littermates showed no rapid auditory processing deficit when compared to non-ectopic females on this same task. Current results add growing support to: (1) an association between focal cortical malformations and impaired auditory processing in males; and (2) the existence of sex differences in the behavioral consequences of focal cortical malformations.
Keywords: acoustic startle response; auditory discrimination; cortical malformations; dyslexia; language impairments; neuromigrational anomalies
DOI: 10.1097/00001756-200212030-00021
Source：NEUROREPORT
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